the delivery of drugs with poor solubility and bioavailability. Hot melt extrusion has been shown to disperse poorly soluble drugs in a polymer carrier molecularly. The procedure encompasses the application of heat, pressure, and agitation to mix materials and 'extrude' them through a tool die. Twin-screw high shear extruders blend materials and break up particles at the same time. The resultant particles can be combined and compressed into tablets or filled into capsules.

Labs may use dry ice to cool drugs for reaction selectivity, but this cooling process becomes complicated if used at an industrial size. The cost of cooling a typical reactor to this temperature is high, and the viscosity of the reagent can increase as the temperature lowers, leading to difficult mixing. This causes the added expense of stirring harder and replacing parts more often, or it leads to a non-homogeneous reaction.